E. Fröhlich, Gudrun Bonstingl, Anita Höfler, C. Meindl, G. Leitinger, T. Pieber, E. Roblegg
2012.8.10TOXICOLOGY IN VITRO
tlooto Summary
Cytotoxicity of amine-functionalized polystyrene nanoparticles was significantly higher when applied as an aerosol on cell cultured in air–liquid interface culture compared with nanoparticle suspensions tested in submersed culture, highlighting the importance of relevant exposure systems.
Abstract
Highlights ► A new VITROCELL – Pariboy system was evaluated for testing of aerosolized NPs. ► Deposition rates differed between marker compounds and NPs. ► The manual aerosolizer MicroSprayer was suitable for cytotoxicity testing of NPs. ► Polystyrene nanoparticles acted more cytotoxic as aerosols than as suspensions.
Citation format
FRÖHLICH, E., et al. Comparison of two in vitro systems to assess cellular effects of nanoparticles-containing aerosols. TOXICOLOGY IN VITRO, 2012, 27: 409–417.