Ning Wang, Shi-Yue Li, Xinglou Yang, Huimin Huang, Yuji Zhang, Hua Guo, Chuming Luo, Maureen Miller, Guang-jian Zhu, Aleksei A. Chmura, E. Hagan, Ji-hua Zhou, Yun-Zhi Zhang, Lin‐Fa Wang, P. Daszak, Zhènglì Shí
2018.2.1VIROLOGICA SINICA
tlooto Summary
This report developed a specific ELISA based on the nucleocapsid protein of a SARSr-CoV strain and detected its antibody in humans who are highly exposed to bat populations and demonstrated the Sarsr- CoV had spillover to humans, although did not cause clinical diseases.
Abstract
In our previous works, we have reported genetically diverse SARS-related coronaviruses (SARSr-CoV) in a single bat cave, Yunnan province, China, and suggested that some SARSr-CoVs may have high potential to infect humans without the necessity for an intermediate host. In this report, we developed a specific ELISA based on the nucleocapsid protein of a SARSr-CoV strain and detected its antibody in humans who are highly exposed to bat populations. From 218 human serum samples, 6 were positive against the nucleocapsid protein by ELISA and further confirmed by Western blot. For the first time, we demonstrated the SARSr-CoV had spillover to humans, although did not cause clinical diseases.
Citation format
WANG, Ning, et al. Serological evidence of bat SARS-Related coronavirus infection in humans, China. VIROLOGICA SINICA, 2018, 33: 104–107.