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BiologyMedicine

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

J. Fontenot, M. Gavin, A. Rudensky

2003.3.3NATURE IMMUNOLOGY

DOI: 10.1038/ni904

tlooto Summary

It is reported that the forkhead transcription factor Foxp3 is specifically expressed in CD4+CD25+ regulatory T cells and is required for their development and function and ectopic expression ofFoxp3 confers suppressor function on peripheral CD4-CD25− T cells.

Abstract

Abstract is not available.

Citation format

FONTENOT, J.; GAVIN, M.; RUDENSKY, A. Foxp3 programs the development and function of CD4+CD25+ regulatory t cells. NATURE IMMUNOLOGY, 2003, 4: 330–336.