Sonal Jangalwe, L. Shultz, A. Mathew, M. Brehm
2016.8.28Immunity Inflammation and Disease
tlooto Summary
Humanized mice engrafted with human immune systems support studies of human hematopoiesis and the immune response to human‐specific pathogens but have a severely restricted ability to undergo class switching and produce antigen‐specific IgG after infection or immunization.
Abstract
Immunodeficient mice engrafted with human immune systems support studies of human hematopoiesis and the immune response to human‐specific pathogens. A significant limitation of these humanized mouse models is, however, a severely restricted ability of human B cells to undergo class switching and produce antigen‐specific IgG after infection or immunization.
Citation format
JANGALWE, Sonal, et al. Improved b cell development in humanized nod‐scid il2rγ mice transgenically expressing human stem cell factor, granulocyte‐macrophage colony‐stimulating factor and interleukin‐3. Immunity Inflammation and Disease, 2016, 4: 427–440.