D. Binder, H. Scharfman
2004.9.1GROWTH FACTORS
tlooto Summary
Since the purification of BDNF in 1982, a great deal of evidence has mounted for its central roles in brain development, physiology, and pathology, and application of the trophic properties ofBDNF may lead to novel therapeutic options in neurodegenerative diseases and perhaps even in neuropsychiatric disorders.
Abstract
Development of useful automatic cell culture system ‘YURIKAGO’ for regenerative therapy We accomplished the following three very important break-through 1) we established technology for Superproliferation of MSC and developed Automatic cell culture system, 2) we conducted pre-clinical tests in animal experiments designed for dental applications and 3) we participated and supported clinical research into actual treatment of periodontal disease. We developed Automatic Cell Culture system for mesencymal stem cells(MSC)‘YURIKAGO’ in 2007. The system has various characteristics 1) size is smaller than other system, 2) weight is lighter than other systems, 3) culture program is all automatic (culture, passage and harvest) and 4) we can proliferate MSC for the vast numbers required for treatment with having kept retention of multilineage differentiation potential. The key to this system is original MSC proliferation technology obtained by TWO CELLS that utilize basic Fibroblast Growth Factor(bFGF) that takes a few MSC and produces the vast numbers required for treatment. It is a wish that an intractable disease can be treated using our system and MSC. Rec.1/6/2009, Acc.5/11/2009, pp329-332 Masanori Sakai1,*), Yuki Katsura1), Hisao Yoshihashi1), Maiko Hara1), Toshihiko Yamagata2), Yukio Kato1,3), and Koichiro Tsuji1) 1) TWO CELLS Co., Ltd. 2)B.E.MARUBISHI Co., Ltd. 3)Graduate School of Biomedical Sciences, Hiroshima University
Citation format
BINDER, D.; SCHARFMAN, H. Brain-derived neurotrophic factor. GROWTH FACTORS, 2004, 22 3: 123–31.