MedicineBiology

Hypoxia-inducible factors in stem cells and cancer

J. Mazumdar, V. Dondeti, M. Simon

2009.11.1JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

DOI: 10.1111/j.1582-4934.2009.00963.x

tlooto Summary

HIF‐1α regulates Notch effects on cellular differentiation and regulates Notch effects on cellular differentiation in HIFs, stem cell pathways and disease.

Abstract

• Introduction • From metabolic adaptation to stem cell signalling • HIF‐1α regulates Notch effects on cellular differentiation • Stem cell pluripotency requires HIF target gene function • O2 regulation of Wnt signalling is differentiation‐stage specific • HIFs, stem cell pathways and disease • HIF and cMyc • HIF and p53

Citation format

MAZUMDAR, J.; DONDETI, V.; SIMON, M. Hypoxia-inducible factors in stem cells and cancer. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2009, 13: 4319–4328.