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Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors

S. Boutin, Virginie Monteilhet, P. Véron, C. Leborgne, O. Benveniste, M. Montus, C. Masurier

2010.4.28HUMAN GENE THERAPY

DOI: 10.1089/hum.2009.182

tlooto Summary

Characterization of the preexisting humoral responses to the AAV capsid and cross-reactivity will allow development of new strategies to circumvent AAV acquired immune responses, and vectors based on AAV5, AAV8, and AAV9 may have an advantage for gene therapy in humans.

Abstract

Abstract is not available.

Citation format

BOUTIN, S., et al. Prevalence of serum igg and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: Implications for gene therapy using AAV vectors. HUMAN GENE THERAPY, 2010, 21: 704–712.