MedicineBiology

Tensional homeostasis and the malignant phenotype.

M. Paszek, Nastaran Zahir, Kandice R Johnson, J. Lakins, G. Rozenberg, A. Gefen, Cynthia A. Reinhart-King, S. Margulies, M. Dembo, D. Boettiger, D. Hammer, V. Weaver

2005.9.1CANCER CELL

DOI: 10.1016/j.ccr.2005.08.010

tlooto Summary

It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.

Abstract

Abstract is not available.

Citation format

PASZEK, M., et al. Tensional homeostasis and the malignant phenotype. CANCER CELL, 2005, 8 3: 241–54.