S. A. Liddelow, Kevin A. Guttenplan, L. Clarke, F. C. Bennett, Christopher J. Bohlen, Lucas Schirmer, Mariko L. Bennett, Alexandra E. Münch, Won-Suk Chung, T. Peterson, D. Wilton, A. Frouin, B. Napier, Nikhil Panicker, M. Kumar, M. Buckwalter, D. Rowitch, V. Dawson, T. Dawson, B. Stevens, B. Barres
2019.7.1Alzheimers & Dementia
tlooto Summary
Quality of education, as measured by reading level, moderated the relationship between cerebrovascular pathology—in the form of WMH—and cognition, however, this relationship was observed primarily among non-Hispanics, indicating that greater quality of education conferred reserve from the negative effect ofWMH on memory and language abilities.
Abstract
reading level and WMH interaction (b1⁄4-.030,[-.061, .002]) on processing speed, indicating that above a specific reading level, WMH had a negative overall effect on speed. Conclusions: Quality of education, as measured by reading level, moderated the relationship between cerebrovascular pathology—in the form of WMH—and cognition. However, this relationship was observed primarily among non-Hispanics, indicating that greater quality of education conferred reserve from the negative effect of WMH on memory and language abilities. Among Hispanics, quality of education did not protect against the effects of WMH on cognition. Between-group differences are likely caused by multiple factors, of which one may be the overall lower cognitive performance and educational levels among Hispanics compared to non-Hispanics. Future analyses will examine whether the relationship between reading level and WMH on cognition affect cognitive trajectories and dementia risk later in life.
Citation format
LIDDELOW, S. A., et al. PL‐03‐01: INGE GRUNDKE‐IQBAL AWARD FOR ALZHEIMER'S RESEARCH: NEUROTOXIC REACTIVE ASTROCYTES ARE INDUCED BY ACTIVATED MICROGLIA. Alzheimers & Dementia, 2019, 15.