L. Sequist, B. A. Waltman, D. Dias-Santagata, S. Digumarthy, Alexa B. Turke, P. Fidias, K. Bergethon, A. Shaw, S. Gettinger, A. Cosper, S. Akhavanfard, R. Heist, J. Temel, J. Christensen, J. Wain, T. Lynch, Kathy Vernovsky, E. Mark, M. Lanuti, A. Iafrate, M. Mino‐Kenudson, J. Engelman
2011.3.23Science Translational Medicine
tlooto सारांश
Detailed genetic and histological analysis of 37 patients with drug-resistant non–small cell lung cancers carrying EGFR mutations provides new insights into the shifting sands of drug resistance evolution in lung cancers and suggests that serial biopsies may be essential in the quest to reverse or even prevent the development ofdrug resistance.
सारांश
Lung cancers undergo dynamic genetic and histological changes upon developing resistance to EGFR inhibitors.
साइटेशन फॉर्मेट
SEQUIST, L., et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Science Translational Medicine, 2011, 3: 75ra26–75ra26.