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Phytoestrogens and Their Human Metabolites Show Distinct Agonistic and Antagonistic Properties on Estrogen Receptor α (ERα)and ERβ in Human Cells

S. O. Mueller, S. Simon, K. Chae, M. Metzler, K. Korach

2004.7.1TOXICOLOGICAL SCIENCES

DOI: 10.1093/toxsci/kfh147

tlooto Summary

All phytoestrogens tested showed reduced potencies to activate ERalpha and ERbeta compared to diethylstilbestrol on the estrogen-responsive C3 promoter compared to a consensus estrogen response element indicating a degree of promoter dependency.

Abstract

Abstract is not available.

Citation format

MUELLER, S. O., et al. Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor α (erα)and ERβ in human cells. TOXICOLOGICAL SCIENCES, 2004, 80: 14–25.