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Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors.

Han van de Waterbeemd, Gian Camenisch, Gerd Folkers, J. Chrétien, O. Raevsky

1998JOURNAL OF DRUG TARGETING

DOI: 10.3109/10611869808997889

tlooto-Zusammenfassung

It is demonstrated that the polar surface area of a drug can be used as a suitable descriptor for the drugs' H-bonding potential, which offers a modern basis for property-based design and targeting of CNS drugs.

Abstract

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Zitationsformat

WATERBEEMD, Han van de, et al. Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and h-bonding descriptors. JOURNAL OF DRUG TARGETING, 1998, 6 2: 151–65.