Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

•  Introduction ‐  Imaging of hypoxic areas ‐  Hypoxia markers ‐  Positron emission tomography (PET) ‐  Near‐infrared spectroscopy (NIRS) ‐  Magnetic resonance spectroscopy (MRS) ‐  Electron paramagnetic resonance spectroscopy (EPR) •  Oxygen partial pressure measurement ‐  Polarographic sensor ‐  Optical sensor ‐  Mass spectrometry •  What does tumour hypoxia mean? •  Small molecules and hypoxia ‐  Chemotherapeutic drugs ‐  Radiation sensitizers: the nitroimidazoles ‐  Hypoxia prodrugs: tirapazimine and anthraquinone ‐  pO2 modulator: myo‐inositol trispyrophosphate (ITPP) ‐  Hypoxia mimetics: dimethyloxallyl glycine, desferrioxamine and metal ions •  What does physioxia mean? ‐  From air to blood ‐  In brain ‐  In lungs ‐  In skin ‐  In intestinal tissue ‐  In liver ‐  In kidney ‐  In muscle ‐  In bone marrow ‐  In umbilical cord blood ‐  To summarize physioxia •  Cellular and molecular consequences of physioxia versus normoxia and hypoxia ‐  Hypoxia inducible factors actions ‐  Role of microRNAs in hypoxia‐dependent regulations ‐  Cell adhesion molecules: their regulation by oxygen partial pressure ‐  Soluble molecules: example of angiogenin •  Conclusion