Ceruloplasmin (2-D PAGE) Pattern and Copper Content in Serum and Brain of Alzheimer Disease Patients
R. Squitti, C. Quattrocchi, G. Forno, Piero G. Antuono, D. Wekstein, C. Capo, C. Salustri, P. Rossini
2007.2.7Biomarker Insights
tlooto Summary
The data show that AD patients have ceruloplasmin fragments of low molecular weight both in their serum and brain, contrary to healthy controls, and suggest a ceruloplasmin fragmentation in the serum of AD patients.
Abstract
Novel, comprehensive approaches for biomarker discovery and validation are urgently needed. One particular area of methodologic need is for discovery of novel genetic biomarkers in complex diseases and traits. Here, we review recent successes in the use of genome wide association (GWA) approaches to identify genetic biomarkers in common human diseases and traits. Such studies are yielding initial insights into the allelic architecture of complex traits. In general, it appears that complex diseases are associated with many common polymorphisms, implying profound genetic heterogeneity between affected individuals.
Citation format
SQUITTI, R., et al. Ceruloplasmin (2-d PAGE) pattern and copper content in serum and brain of alzheimer disease patients. Biomarker Insights, 2007, 1: 205–213.