BiologyMedicine

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

P. A. Gregory, A. Bert, Emily Paterson, S. Barry, A. Tsykin, G. Farshid, M. Vadas, Y. Khew-Goodall, G. Goodall

2008.5.1NATURE CELL BIOLOGY

DOI: 10.1038/ncb1722

tlooto Summary

It is found that all five members of the microRNA-200 family were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-β or to ectopic expression of the protein tyrosine phosphatase Pez, suggesting that downregulation of themicroRNAs may be an important step in tumour progression.

Abstract

Abstract is not available.

Citation format

GREGORY, P. A., et al. The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. NATURE CELL BIOLOGY, 2008, 10: 593–601.