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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development.

W. Redfern, L. Carlsson, A. S. Davis, W. G. Lynch, I. Mackenzie, S. Palethorpe, P. Siegl, I. Strang, A. Sullivan, R. Wallis, A. Camm, T. Hammond

2003.4.1CARDIOVASCULAR RESEARCH

DOI: 10.1016/s0008-6363(02)00846-5

tlooto Summary

The dataset confirms the widely-held belief that most drugs associated with TdP in humans are also associated with hERG K(+) channel block at concentrations close to or superimposed upon the free plasma concentrations found in clinical use.

Abstract

Abstract is not available.

Citation format

REDFERN, W., et al. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development. CARDIOVASCULAR RESEARCH, 2003, 58 1: 32–45.