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ChemistryMedicine

Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses.

Erin E. Chambers, Diane M. Wagrowski-Diehl, Ziling Lu, J. Mazzeo

2007.6.1JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

DOI: 10.1016/j.jchromb.2006.12.030

tlooto Summary

The combination of polymeric mixed-mode SPE, the appropriate mobile phase pH and UPLC technology provides significant advantages for reducing matrix effects resulting from plasma matrix components and in improving the ruggedness and sensitivity of bioanalytical methods.

Abstract

Abstract is not available.

Citation format

CHAMBERS, Erin E., et al. Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2007, 852 1-2: 22–34.