V. Mootha, C. Lindgren, K. Eriksson, A. Subramanian, S. Sihag, J. Lehár, P. Puigserver, E. Carlsson, M. Ridderstråle, E. Laurila, Nicholas Houstis, M. Daly, N. Patterson, J. Mesirov, T. Golub, P. Tamayo, B. Spiegelman, E. Lander, J. Hirschhorn, D. Altshuler, L. Groop
2003.7.1NATURE GENETICS
tlooto Summary
An analytical strategy is introduced, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes, which identifies a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle.
Abstract
Abstract is not available.
Citation format
MOOTHA, V., et al. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. NATURE GENETICS, 2003, 34: 267–273.