A. Schlegel, P. Kron, P. Dutkowski
2015.2.10Current Transplantation Reports
tlooto Summary
This review summarizes current knowledge of this perfusion technique for liver preservation and provides an overview of possible pathways of protection from ischemia-reperfusion injury.
Abstract
Dynamic preservation strategies such as hypothermic machine perfusion are increasingly discussed to improve liver graft quality before transplantation. This review summarizes current knowledge of this perfusion technique for liver preservation. We discuss optimization of perfusion conditions and current strategies to assess graft quality during cold perfusion. Next, we provide an overview of possible pathways of protection from ischemia-reperfusion injury. Finally, we report on recent clinical applications of human hypothermic machine liver perfusion.
Citation format
SCHLEGEL, A.; KRON, P.; DUTKOWSKI, P. Hypothermic oxygenated liver perfusion: Basic mechanisms and clinical application. Current Transplantation Reports, 2015, 2: 52–62.