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The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment.

A. Greenhough, H. Smartt, A. E. Moore, Heather R. Roberts, A. Williams, C. Paraskeva, Abderrahmane Kaidi

2009.3.1CARCINOGENESIS

DOI: 10.1093/carcin/bgp014

tlooto Summary

A model for the cellular adaptation to the hypoxic tumour microenvironment that encompasses the interplay between COX-2, hypoxia-inducible factor 1 and dynamic switches in beta-catenin function that fine-tune signalling networks to meet the ever-changing demands of a tumour is proposed.

Abstract

Abstract is not available.

Citation format

GREENHOUGH, A., et al. The COX-2/PGE2 pathway: Key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. CARCINOGENESIS, 2009, 30 3: 377–86.