Preparation of Silybin Nanoemulsion and Its Pharmacokinetics in Rabbits

AIM:To prepare stable silybin nanoemulsion for intramuscular injection and to study the in vivo disposition behaviors.METHODS:Silybin-phospholipid complex was prepared to enhance silybin′s solubility in the oil;The formulation of the silybin nanoemulsion was optimized by the uniform design;Following administration of the nanoemulsion to rabbits,the in vivo disposition of silybin was evaluated.RESULTS:The silybin nanoemulsion with optimized formulation was stable with the average paritcle size being 21.2 nm and Zeta potential being-26.9 mV.And the release profile in rabbits showed a sustained-release manner.CONCLUSION:Silybin nanoemulsion for intramuscular injection could increase silybin MRT in vivo.In comparison to silybin aqueous injection,the intramuscularly injected nanoemulsion could sustain the in vivo release of silybin with improved bioavailability.