Syphilis - its early history and treatment until penicillin, and the debate on its origins

In 1495 an epidemic of a new and terrible disease broke out among the soldiers of Charles VIII of France when he invaded Naples in the first of the Italian Wars, and its subsequent impact on the peoples of Europe was devastating – this was syphilis, or grande verole, the “great pox”. Although it didn’t have the horrendous mortality of the bubonic plague, its symptoms were painful and repulsive – the appearance of genital sores, followed by foul abscesses and ulcers over the rest of the body and severe pains. The remedies were few and hardly efficacious, the mercury inunctions and suffumigations that people endured were painful and many patients died of mercury poisoning.