V. Y. Novikov, O. Levchenkova
tlooto Summary
Pharmacological influence on HIF-1α for a target upregulation of processes of immediate and delayed organism adaptation to Hypoxia opens new possibilities of effective pharmacotherapy of oncological, rheumatic, cardio-vascular and other diseases which have hypoxia and ischemia in their pathogenetic state.
Abstract
The review is devoted to the role of specific regulatory protein HIF-1α (hypoxia-induced factor-1alpha) in the mechanisms of the organism adaptation to hypoxia. Pharmacological influence on HIF-1α for a target upregulation of processes of immediate and delayed organism adaptation to hypoxia is discussed in the article. Such approach opens new possibilities of effective pharmacotherapy of oncological, rheumatic, cardio-vascular and other diseases which have hypoxia and ischemia in their pathogenetic state.
Citation format
NOVIKOV, V. Y.; LEVCHENKOVA, O. Hypoxia-inducible factor as a pharmacological target. Reviews on Clinical Pharmacology and Drug Therapy, 2013, 11: 8–16.