Inhibition of periplocin on human hepatoma carcinoma and breast carcinoma cells in vitro

Objective To discuss the effect of periplocin on the proliferation of the breast carcinoma MDA-MB-468 cells and hepatocellular carcinoma HepG2 cells in vitro. Methods MTT method was used to examine the proliferation of MDA-MB-468 and HepG2 cells, and flow cytometry was used to observe the effect of periplocin on cell cycle of the two kinds of tumer cells. Results Compared with the control group, periplocin could obviously inhibit the proliferation of two kinds of cells, and the inhibitory rate was positively correlated with drug level and action time. By flow cytometry, it was found that after 24 h treatment, periplocin induced cell cycle(G0 /G1) arrest in MDA-MB-468 and HepG2 cells. Conclusion Periplocin could inhibit the proliferation of the breast carcinoma MDA-MB-468 and hepatocellular carcinoma HepG2 cells, and block their cell cycle in G0 /G1 phase.