V. Novikov, Новиков Василий Егорович, O. Levchenkova, Левченкова Ольга Сергеевна, Yelena Vasilyevna Pozhilova, Пожилова Елена Васильевна
tlooto Summary
Analysis of modern scientific investigations about role of reactive oxygen species (ROS) in physiology and pathophysiology of cell and possibility of pharmacological regulation of the activity of free radical oxidation reactions are analyzed.
Abstract
This review is devoted to analysis of modern scientific investigations about role of reactive oxygen species (ROS) in physiology and pathophysiology of cell. Key issues of ROS generation, their function in signaling pathways, role in the cellular pathology, functioning of antioxidant system are discussed in the paper. The review also summarizes literature data about possibility of pharmacological regulation of the activity of free radical oxidation reactions, which have practical value for effective pharmacotherapy of diseases in pathogenesis of which destructive action of ROS is present.
Citation format
NOVIKOV, V., et al. Role of reactive oxygen species in cell physiology and pathology and their pharmacological regulation. Reviews on Clinical Pharmacology and Drug Therapy, 2014, 12: 13–21.