Gene deletion polymorphisms of GSTT1 and GSTM1 and susceptibility to stomach neoplasm

Objective To study the association between GSTTI and GSTM1 gene deletion polymorphisms and susceptibility to gtomach neoplasm. Methods Genotype of GSTT1 and GSTM1 was detected using PCR technique from 92 patients with stomach neoplasm and 92 controls. A case-control study was performed. Results The frequency of the GSTT1 gene deletion was 53.3% and 41.3%, respectively in cases and controls, and their difference was not statistically significant (x 2=2.64 P=0.104). But the frequency of the homozygous deleted genotype (GSTM1-/-) was 69.6% and 52.2%, respectively in patients and controls (OR=2.10 95%CI=1.10~4.01). Persons with GSTM1(-) genotype had 2.1-fold risk for developing stomach neoplasm than those with GSTM1(+) (OR=4.67 95%CI=1.55~14.41). The results showed that the GSTT1 and GSTM1 gene had combined action, those with GSTT1(-) and GSTM1(-) genotype had significantly higher risk of developing stomach neoplasm than those with GSTT1(+) and GSTM(+). Conclusion GSTM1 gene deletion may be one of risk factors contributing to development of stomach neoplasm.