Effect of Gibberellins and Its Synthetic Inhibitor on Metabolism of Tanshinones

Objective:To study the effect of gibberellins and its synthetic inhibitor on tanshinones. Methods: Different concentrations of gibberellins and paclobutrazol were added to the liquid medium, and hairy roots of Salvia miltiorrhiza Bge.were cultivated for 25 days. The concentration of cryptotanshinone, tanshinone Ⅰ and tanshinone Ⅱ_A in the samples were assayed by HPLC. Results: The concentration of cryptotanshinone, tanshinone Ⅰ and tanshinone Ⅱ_A increased in the samples treated with gibberellins, while the concentration of cryptotanshinone, tanshinone Ⅰ and tanshinone Ⅱ_A decreased in the samples treated with paclobutrazol. Conclusions: Paclobutrazol could be synthetic inhibitor of tanshinone Ⅱ_A, and gibberellins can be inducer for production of tanshinones.