Ceftaroline:a new cephalosporin with activity against resistant Gram-positive pathogens

Ceftaroline fosamil is a novel,parenteral,broad-spectrum cephalosporin exhibiting bactericidal activity against Gram-positive organisms,including MRSA and multidrug-resistant Streptococcus pneumoniae(MDRSP),as well as common Gram-negative pathogens.On Oct.29,2010,the U.S.Food and Drug Administration approved ceftaroline fosamil to treat adults with community acquired bacterial pneumonia(CABP) and acute bacterial skin and skin structure infections(ABSSSI),including methicillin-resistant Staphylococcus aureus(MRSA).The chemistry and structure-activity relationship,antibacterial activity,pharmacokinetics,pharmacodynamics,therapeutic efficacy,adverse effects were reviewed in this paper.