W. G. Hill
1981.12.1Genetics Research
tlooto Summary
A method is proposed for estimating effective population size from data on linkage disequilibrium among neutral genes at several polymorphic loci or restriction sites, but for very tightly linked genes estimates of N are more dependent on long-term than on recent population history.
Abstract
SUMMARY A method is proposed for estimating effective population size ( N ) from data on linkage disequilibrium among neutral genes at several polymorphic loci or restriction sites. The efficiency of the method increases with larger sample size and more tightly linked genes; but for very tightly linked genes estimates of N are more dependent on long-term than on recent population history. Two sets of data are analysed as examples.
Citation format
HILL, W. G. Estimation of effective population size from data on linkage disequilibrium. Genetics Research, 1981, 38: 209–216.