MedicineBiology

ATF4, Hypoxia and Treatment Resistance in Cancer

D. Singleton, A. Harris

2019Cancer Drug Discovery and Development

DOI: 10.1007/978-3-030-05067-2_4

tlooto Summary

Under conditions of persistent and unresolved stress, ATF4 transcriptional reprogramming becomes pro-apoptotic, and therapeutic modulators of ATF4 signaling have the potential to modify these properties by diminishing adaptive phenotypes in cancer cells.

Abstract

Abstract is not available.

Citation format

SINGLETON, D.; HARRIS, A. ATF4, hypoxia and treatment resistance in cancer. Cancer Drug Discovery and Development, 2019.