The incidence,natural history, biology, and treatment of transformed lymphomas

1 or 2 grade FL followed by a diffuse large cell lymphoma(DLCL) ot a Burkitt/Burkitt-like lymphoma is TL. TL maintains a phenotype suggestive of germinal center derivation. The most common immunophenotype is the same as that of FL, CD+10/bcl-6+. Obtaining a biopsy of TL is enhanced if the biopsy is directed to the site with the greatest SUV. The risk of transformation of about 30% at 10 years after the initial diagnosis of FL. The median duration of survival after transformation generally ranging from 1 to 2 years.HDCT-ASCT, allogeneic tranplantation, radioimmunotherapy and bendamustine are the possible therapy for TL. Key words: Follicular lymphoma; Transformation