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A rapid esterification by means of mixed anhydride and its application to large-ring lactonization.

J. Inanaga, K. Hirata, H. Saeki, T. Katsuki*, M. Yamaguchi

1979.7.1BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

DOI: 10.1246/bcsj.52.1989

tlooto Summary

Rapid esterification method using carboxylic 2,4,6-trichlorobenzoic anhydrides and 4-dimethylaminopyridine for large-ring lactonization

Abstract

A rapid and mild esterification method using carboxylic 2,4,6-trichlorobenzoic anhydrides in the presence of 4-dimethylaminopyridine was developed. The method was also successfully applied to the synthesis of large-ring lactones, including DL-2,4,6-tridemethyl-3-deoxymethynolide.

Citation format

INANAGA, J., et al. A rapid esterification by means of mixed anhydride and its application to large-ring lactonization. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1979, 52: 1989–1993.