Synthesis, antimicrobial activity and Electron Impact of Mass Spectra of Phthalazine-1,4-dione Derivatives

Reactions of 3-aminothiocarbonylphthalazine-1,4-dione (2) with aromatic aldehydes, benzoyl chloride, benzoin and ω-bromomethylarylketones yielded the corresponding 3-(substituted amino)thiocarbonylphthalazine-1,4-diones (3, 8, and 9) and 4-aryl-1-thioxo-1,2,4-triazino[1,2-b] phthalazine-5,10-diones (7). Acylation of 3b with acetic anhydride gave the corresponding diacetyl derivative (4). The electron impact mass spectra of both the above series of compounds have also been recorded and their fragmentation pattern is discussed.