ChemistryMedicine

Role of Physicochemical Properties and Ligand Lipophilicity Efficiency in Addressing Drug Safety Risks

M. Edwards, David A. Price

2010Annual Reports in Medicinal Chemistry

DOI: 10.1016/s0065-7743(10)45023-x

tlooto Summary

This chapter summarizes recent developments regarding the role of physicochemical properties in safety liability and the emerging use of physic biochemical property-based lead optimization using lipophilic ligand efficiency (LLE or LipE).

Abstract

Abstract is not available.

Citation format

EDWARDS, M.; PRICE, David A. Role of physicochemical properties and ligand lipophilicity efficiency in addressing drug safety risks. Annual Reports in Medicinal Chemistry, 2010, 45: 380–391.