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Open AccessChemistry

Lipase-Catalyzed Dynamic Kinetic Resolution of Chiral Amines: Use of Palladium as the Racemization Catalyst

M. Reetz, K. Schimossek

1996.12.18CHIMIA

DOI: 10.2533/chimia.1996.668

tlooto Summary

The simultaneous use of a biocatalyst (lipase Candida antarctica) and a transition-metal catalyst (palladium) makes the dynamic kinetic resolution of racemic phenylethylamine possible, conversion to the enantiomerically pure N-acylated form being 75–77%.

Abstract

The simultaneous use of a biocatalyst (lipase Candida antarctica) and a transition-metal catalyst (palladium) makes the dynamic kinetic resolution of racemic phenylethylamine possible, conversion to the enantiomerically pure N-acylated form being 75–77% (ee = 99%).

Citation format

REETZ, M.; SCHIMOSSEK, K. Lipase-catalyzed dynamic kinetic resolution of chiral amines: Use of palladium as the racemization catalyst. CHIMIA, 1996.