Antitumor Constituents from the Leaves of Aquilaria sinensis (Lour.) Gilg

Based on screening of antitumor activity,antitumor constituents in the crude extract from the leaves of Aquilaria sinensis(Lour.)Gilg,were isolated and purified by various chromatographic methods and were identified on the basis of spectral analysis and physico-chemical characters.Ten compounds were identified as 5-hydroxy-7,4'-dimethoxyflavone(1),luteolin-7,3',4'-trimethyl(2),luteolin-7,4'-dimethyl(3),genkwanin(4),luteolin(5),3'-hydroxygenkwanin(6),2-O-α-L-rhamnopy-ranosyl-4,6,4'-trihydroxybenzo-phenone(7),4-hydroxybenzoic acid(8),β-daucosterol(9),7α-hydroxysitosterol(10),respectively.The novel compound 7 was found for the first time.Compounds 1-6 and 8,10 were isolated from this plant for the first time.