Medicine
R. Brimblecombe, W. M. Duncan, G. J. Durant, J. C. Emmett, C. R. Ganellin, M. E. Parsons
tlooto Summary
Cimetidine is a specific competitive histamine H2-receptor antagonist and is an effective inhibitor of gastric secretion in animals and man with similar pharmacological properties to metiamide.
Abstract
Cimetidine is a non-thiourea analogue of metiamide. It is a specific competitive histamine H 2 -receptor antagonist and is an effective inhibitor of gastric secretion in animals and man with similar pharmacological properties to metiamide. No renal damage or haematological changes were observed in 90-day studies in rats or dogs.
Citation format
BRIMBLECOMBE, R., et al. Cimetidine—a non-thiourea h2-receptor antagonist. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 1975, 3: 86–92.