Clinical Value of N-terminal Pro-brain Natriuretic Peptide and Cardial Troponin I for Evaluating the Patients With Acute Pulmonary Embolism Combining Right Ventricular Dysfunction

Objective:To explore the clinical value of N-terminal Pro-brain natriuretic peptide(NT-Pro BNP) and cardial troponin I(c Tn I) for evaluating the patients with acute pulmonary embolism(APE) combining right ventricular dysfunction(RVD).Methods:A total 92 APE patients treated in our hospital were studied.The blood levels of NT-Pro BNP and c Tn I were measured on next morning of administration and echocardiography was performed within 24 hours of APE diagnosis.According to echocardiographic results,the patients were divided into 2 groups:APE with RVD group,n =47 and APE without RVD group,n =45.Blood levels of NT-Pro BNP and c Tn I were compared between 2 groups.Results:Compared with APE without RVD group,APE with RVD group presented increased levels of NT-Pro BNP,c Tn I and right ventricular end-diastolic diameter(RVEDD),all P 0.01.ROC curve analysis found that both AUC of NT-Pro BNP and c Tn I 90%,the optimum operating point for NT-Pro BNP and c Tn I were 554 pg/ml and 0.09 ng/ml respectively.Logistic regression analysis showed that NT-Pro BNP(r =1.227,P =0.005),c Tn I(r =0.862,P =0.016),right ventricular dysfunction(r =0.936,P =0.008) and heart rate(r =0.809,P =0.023) were related to poor prognosis for inhospital patients.Conclusion:Blood levels of NT-Pro BNP and c Tn I may help diagnosing the patients with acute pulmonary embolism with right ventricular dysfunction,it may also predict the short term prognosis in clinical practice.