Age‐related behavioral changes from young to old age in male mice of a C57BL/6J strain maintained under a genetic stability program

Aging is thought to coincide with gradual and progressive changes in brain function and behavior over the lifetime. Our previous meta‐analytic study reported age‐related behavioral changes from young to middle age in male C57BL/6J mice. However, the previous study had some limitations that could affect the generalizability of the findings because of the potential influence of genetic and environmental factors on behavior, in addition to a lack of information regarding the behaviors of old‐aged mice. Here, to investigate age‐related behavioral changes from young to old age in mice, we analyzed the behaviors of male C57BL/6J mice from four different age groups (8, 47, 73, and 99 weeks of age at the beginning of the experiment) from a colony that had been maintained in a genetically controlled condition based on The Jackson Laboratory's Genetic Stability Program in an environmentally controlled animal facility.