Monocyte-to-high density lipoprotein ratio (MHR) can predict the significance of angiographically intermediate coronary lesions

Abstract Purpose Monocyte-high density lipoprotein ratio (MHR) has recently emerged as a marker of inflammation and oxidative stress in the cardiovascular disease. We aimed to investigate whether baseline MHR is associated with functional significance of intermediate coronary artery lesions. Methods Three hundred and one consecutive patients, 215 males and 86 females, who underwent fractional flow reserve (FFR) measurement for angiographically intermediate coronary stenosis (40–70% in quantitative coronary analysis) in the left anterior descending coronary artery were enrolled into the study. An FFR value of ≤ 0.80 was accepted for hemodynamic significance. Results Of the 301 patients, 115 (38.2%) exhibited significant functional stenosis (FFR ≤ 0.80) in the FFR measurement. Patients with hemodynamically significant lesions had higher MHR values (11.6 ± 3.3 vs. 12.6 ± 2.5 p = 0.003).In stepwise multivariate logistic regression analysis, total cholesterol (OR = 1.008, 95% CI = 1.002–1.013, p  Conclusions Increased MHR values were associated with functional significance of angiographically intermediate coronary artery stenosis.