Analysis of influence factors and survival of liver transplantation for primary hepatocellular carcinoma:a report of 109 cases

Objective Analysis of effect factors and survival of liver transplantation for primary hepatocellular carcinoma(HCC).Methods The clinical data of 109 patients underwent liver transplantation for HCC between January 2004 to December 2007 at the Liver Transplantation Center of Third Affiliated Hospital of Sun Yat-sen University were analyzed retrospectively.The Kaplan-Meier method was used to evaluate the cumulative survival rate and tumor-free survival rate.Log-rank test and Cox regression model were used to analysis the single and muti-factor for tumor-free survival rate respectively.Results Among 109 cases,there were 37 patients(33.9%)developed tumor recurrence.The 1-year,3-year,5-year cumulative survival rates were 86.9%,66.1%,56.6%.The 1-year,3-year,5-year tumor-free survival rates were 78.3%,64.7%,53.1%.Single analysis showed that preoperative size of tumor,vascular invasion,pathology differentiation were effect on tumor-free survival rates of HCC after liver transplantation.Cox regression model analysis showed that the preoperative vascular invasion,pathology differentiation were independent risk factors of tumor-free survival rate.Conclusion The independent risk factors of tumor-free survival rate of liver transplantation for HCC include preoperative vascular invasion and pathological differentiation.Strict selection of indication of liver transplantation for HCC can reduce the rate of recurrence of tumor.