Observation on the level of antibodies of measles, mumps and rubella in Shanghai

Objective To understand the level of antibodies of measles mumps and rubella in healthy people after rubella vaccine and MMR in Shanghai. [Methods] 543 healthy people's sera from 0-50 years old were assayed for antibodies of measles,mumps and rubella. [Results] GMT of measles antibody was the lowest in babies less than 8 months, and in 8-month group rose markedly (P0.001) after vaccination. Antibody of GMT 8 months and 8-month were less than 1∶10, and antibody GMT of 1 year after vaccination rose markedly (P0.001). Although the antibody level was decreasing with age, the positive rate still maintained above 85%. GMT of mumps antibody in 8 months and 8-month was less than 1∶5, it rose markedly one year after vaccination (P0.001). [Conclusion] The results of analysis shows that the recent vaccination process of measles and MMR in Shanghai are comparatively reasonable and effective, but further researches of rubella antibody level and persistent observation of MMR vaccination are necessary for childbearing women. Meanwhile, studies on vaccination strategy of measles for pre-vaccinating child and childbearing women are both essential to prevent congenital rubella syndrome (CRS).