Expression of fetal fibronectin in early pregnant women with recurrent spontaneous abortion

Objective To observe the expression of fetal fibronectin( f FN) in early pregnancy of gestation again in recurrent spontaneous abortion( RSA) women and explore its predictive value for pregnant outcome of RSA patients. Methods Ninety-three early pregnant women with RSA history between June 2013 and November 2014 were selected as observed group,and 50 normal early pregnant women at the same time were selected as control group. The f FN was detected by forward light immunity analyzer. The sample of f FN concentration more than 50 ng / ml was defined as positive,and otherwise was defined as negative. The positive expression rates of f FN and embryo loss rate in two groups were compared. The sensitivity,specificity,positive predictive value and negative predictive value for the f FN as a predictive index were observed. The risk factors of embryo loss during gestation again in RSA patients were analyzed. Results The positive rate of f FN in observed group was significantly higher than that in control group( 79. 57% vs 34. 00%,P 0. 01),and the embryo loss rate in observed group was also significantly higher than that in control group( 61. 29% vs 16. 00%,P 0. 01). The overall sensitivity( 92. 85%) and negative predictive value( 90. 38%) were satisfactory,but the specificity( 64. 38%) and positive predictive value( 71. 43%) were poor. The logistic regression analysis showed that reproductive system infections( OR = 1. 201,P = 0. 008),anatomic abnormalities( OR = 1. 092,P = 0. 032) and immune abnormalities( OR = 1. 422,P =0. 002) were the risk factors of embryo loss during gestation again in RSA patients. Conclusions The f FN can better predict the outcome of early pregnancy in RSA patients,but its application needs further to be explored.