Effect of sodium tanshinon IIA silate injection on acute pancreatitis

Objective To investigate the effect of sodium tanshinon ⅡA silate injection on acute pancreatitis( AP).Methods Sixty-five patients with AP were divided into observation group( n = 34) and control group( n = 31). The patients in the two groups were treated with fasting,oxygen inhalation,gastrointestinal decompression,infection prevention,early enteral nutrition and other conventional treatment. Based on the conventional treatment,the patients in control group were treated with ulinastatin 100 000 u by intravenous drip,twice a day for two courses of treatment,one week as a course of treatment; the patients in observation group were treated with sodium tanshinon ⅡA silate injection 40 mg by intravenous drip,once a day for two courses of treatment,one week as a course of treatment. The curative effect was compared between the two groups after treatment. Results The recovery time of body temperature,stomachache,jaundice and the hospitalization time in observation group were significantly shorter than those in control group( P 0. 05). There was no significant difference in the level of serum amylase,lipase,fasting blood glucose and erythrocyte sedimentation rate( ESR) between the two groups before treatment( P 0. 05). The levels of serum amylase,lipase,fasting blood glucose and ESR after treatment were significantly lower than those before treatment in the two groups( P 0. 05). The levels of serum amylase,lipase,fasting blood glucose and erythrocyte sedimentation rate in observation group were significantly lower than those in control group after treatment( P 0. 05). The white blood cell( WBC) and serum C-realtive protein( CRP) level at the third,fifth,seventh and fourteenth day of treatment were significantly lower than those before treatment and at the first day of treatment( P 0. 05). The WBC and serum CRP level in observation group were significantly lower than those in control group at the third,fifth,seventh and fourteenth day of treatment( P 0. 05). Conclusion Sodium tanshinon ⅡA silate can significantly improve clinical symptoms,recover the function of the pancreas,reduce pancreatic inflammation and increase the effect of treatment in patients with AP.