Clinical Features and Prognostic Factors for the Patients with Bone Metastases from Non-small-cell Lung Cancer

Objective:To identify clinical features and independent predictors of survival in patients with bone metastases from non-small-cell lung cancer(NSCLC).Methods:We retrospectively analyzed 148 patients with bone metastases from NSCLC between 1997 and 2007.Survival rates were achieved by Kaplan-meier method,univariate analysis was by Log-rank.Multivariate analysis were performed using cox regression models.Results:One-,2-,3-year survival were 52.2%,26.5%,3.7%,respeetively.The median suruival time was 13.0 months for patients with bone metastases from NSCLC.On univariate analysis,number of bone lesions,ALP level were prognostic factors,(P0.05).On multivariate analysis using Cox regression method,stage,ALP level,other organ metastases,number of bone lesions were prognostic factors.Conclusion:This study provides detailed information about clinical features,survival outcomes,and prognostic factors for NSCLC with bone metastases.These prognostic factors will help in determining which dose and fraction are appropriate.