Analysis of risk factors for acute renal failure in the early stage after liver transplantation

Objective To investigate the risk factors for acute renal failure(ARF)in the early stage after liver transplantation.Methods The 362 patients who underwent liver transplantation with full clinical data were selected as research object.They were divided into ARF group(n=71)and non-ARF group(n=291)according to whether occurrence of ARF in the early stage(within 1 month)after transplantation.One-way analysis was used in 36 possible perioperative risk factors.Logistic stepwise regression analysis was used in variables with P0.05 in one-way analysis.Results According to the result of one-way analysis,12 variables,including hepatic encephalopathy pre-transplantation,serum creatinine(Scr)pre-transplantation,hemoglobin pre-transplantation,thrombinogen activity pre-transplantation,total bilirubin pre-transplantation,scores of model for end-stage liver disease(MELD),total operation time,intraoperative blood loss,intraoperative blood transfusion,intraoperative urine output,intraoperative low blood pressure and postoperative infection,had significant difference between two groups(P0.05-0.001).Logistic stepwise regression analysis for 12 variables demonstrated that the increase of Scr pre-transplantation[odds ratio(OR)=0.92],the decrease of thrombinogen activity pre-transplantation(OR=1.015),high MELD scores(OR=1.588),the large volume of intraoperative blood loss(OR=1.012)and infection post-transplantation(OR=12.260)had close relationship with ARF after liver transplantation(all in P 0.05).Conclusions The increase of Scr pre-transplantation,the decrease of thrombinogen activity pre-transplantation,high MELD scores,the large vo-lume of intraoperative blood loss and infection post-transplantation are the independent risk factors of ARF in the early stage after liver transplantation.