Medicine

S. Jurici, Annie Laquerrière, A. Bédat-Millet, F. Jardin, Lucile Musset, J. Vallat, Didier Hannequin, O. Martinaud

2011.9.1Case Reports in Neurology

DOI: 10.1159/000335004

tlooto Summary

The present case of a 71-year-old woman with typical signs of bulbar amyotrophic lateral sclerosis associated with immunoglobulin M (IgM) monoclonal gammopathy and anti-MAG (myelin-associated glycoprotein) antibodies demonstrated no causative link between anti-MAG antibodies and ALS.

Abstract

We report the case of a 71-year-old woman with typical signs of bulbar amyotrophic lateral sclerosis (ALS) associated with immunoglobulin M (IgM) monoclonal gammopathy and anti-MAG (myelin-associated glycoprotein) antibodies. This unusual association between ALS and anti-MAG antibodies has previously been reported in a single case. Our present case, at neuropathological examination, demonstrated no causative link between anti-MAG antibodies and ALS.

Citation format

JURICI, S., et al. An autopsy case of amyotrophic lateral sclerosis with waldenström macroglobulinemia and anti-mag gammopathy. Case Reports in Neurology, 2011, 3: 294–300.