N. Desai, D. Vaja, Krunalsinh A. Jadeja, S. Joshi, V. Khedkar
2020.8.31Anti-Infective Agents
tlooto Summary
In continuation of the efforts to find new antimicrobials, the synthesis of various pyrazole, pyrazoline, and pyridine based novel bioactive heterocycles (3a-t) are reported, which showed significant antimicrobial activity.
Abstract
In continuation of our efforts to find new antimicrobials, herein we report the synthesis of various pyrazole, pyrazoline, and pyridine based novel bioactive heterocycles (3a-t).
Newly synthesized compounds were analysed for their antimicrobial activity. Compounds 3c, 3h, 3i, 3k, 3n, and 3q showed significant antimicrobial activity.
Molecular docking study for the most active analogues against DNA gyrase subunit b (PDB ID: 1KZN) corroborated well with the observed antimicrobial potency exhibiting significant binding affinity.
Interpretation of the chemical structures reported in this paper was based on IR, 1H NMR, 13C NMR, and mass spectral data.
Citation format
DESAI, N., et al. Synthesis, biological evaluation and molecular docking study of pyrazole, pyrazoline clubbed pyridine as potential antimicrobial agents. Anti-Infective Agents, 2020.