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Medicine

The Discovery of Sofosbuvir: A Liver-Targeted Nucleotide Prodrug for the Treatment and Cure of HCV

M. Sofia, P. Furman

2019Topics in Medicinal Chemistry

DOI: 10.1007/7355_2018_37

tlooto Summary

This chapter describes the discovery and development of sofosbuvir, the first live-targeting prodrug of a nucleotide analog, and contains a detailed overview of the synthesis, activity, mechanism of action, toxicity, and clinical studies of sofsbuvir (PSI-7977).

Abstract

Abstract is not available.

Citation format

SOFIA, M.; FURMAN, P. The discovery of sofosbuvir: A liver-targeted nucleotide prodrug for the treatment and cure of HCV. Topics in Medicinal Chemistry, 2019.