Investigation of salivary and serum immunoglobulin, Cytokines, steroid hormone levels in breast cancer

Objective: To study the serum and salivary levels of some Cytokines, immunoglobulin and  steroid hormone  in breast cancer in different pathological stages of the concentration. Methods : The study was conducted on newly-diagnosed breast cancer patients who had not received any treatment. Controls were women not known to have any breast disease or hormone-related tumours. A total of 75 patients with breast cancer were divided into stage I, II and III according to clinical pathology and 45 healthy subjects were selected as control group. Serum and salivary Cytokines ( IL-6,TNF-α  and IL-8)   immunoglobulin (IgG and  IgA ,)  steroid hormone(Estrogen, Progesterone , Testosterone .,) levels were measured and compared of all subjects. Results: The results demonstrated significantly high values of serum and salivary IgG, IgA ,TNF-α,IL-6  , IL-8  estrogen, progesterone, and  testosterone) (P=0.0001) P<0.05, p<0.01, p < 0.0001)  (p<0.001,p<0.01, p<0.05, ) respectively in breast cancer in comparison with control group. Conclusion: An elevation of serum steroid hormone, immunoglobulins (IgA, IgG, IgM),and Cytokines levels in cases of carcinoma breast in this  study is signifies, and its importance as a marker of the breast cancer . Analyzing serum  and salivary cytokine ,steroid hormone and immunoglobulins levels might help identify patients with a poor prognosis who may benefit from more aggressive disease management.